Effect of Phenytoin Sodium on the Biochemical Parameters of Reproductive Function in Male Albino Wistar Rats
نویسندگان
چکیده
To assess the effects of phenytoin sodium on biochemical markers of testicular function. Male Wistar rats (12 weeks old) were treated with phenytoin and sacrificed at the end of 2, 4, 5, 7, 10 and 15 week after the last exposure to phenytoin sodium. The testes were removed, weighed and processed for biochemical analysis. The intratesticular testosterone level was significantly (P<0.001) reduced with 50 mg/kg and 100mg/kg treated rats. The intratesticular lactate dehydrogenase (LDH) level was significantly (P<0.001) increased by phenytoin in a time dependent manner regardless of dose. Phenytoin causes reversible change in testosterone and LDH level.
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